Insights

How to Use Digital Ads for Patient Recruitment in Clinical Trials

Eric Mago Nielsen
January 24, 2025

Patient recruitment for clinical trials has traditionally been a time-consuming and costly process. Before the advent of digital technology, clinical trials primarily relied on physician referrals, word-of-mouth, and traditional advertising methods such as print media. While these methods provided value, their outreach was significantly limited compared to the possibilities offered by digital advertising today.

For organizations seeking a more effective and cost-efficient way to recruit patients for clinical trials, digital advertising has become a game-changer. Below, we explore how this approach can broaden outreach, streamline recruitment, and help meet critical study deadlines.

Using the right channels to advertise a clinical trial is crucial for reaching the target number of study participants and meeting scheduling targets. Some of the benefits of digital marketing and ways to use it to more effectively reach these goals are listed below.

Why Digital Advertising is Revolutionizing Industries, Including Clinical Trial Advertising

In today’s fast-paced world, digital marketing is quickly outpacing traditional methods such as radio and television. Companies across industries are increasingly shifting to digital strategies to capture and engage their target audiences.


The Decline of Traditional Media and the Rise of Digital Consumption

The consumption of traditional media is steadily shrinking as consumers spend more time engaging with digital platforms. In 2019, the average American spent 333 minutes per day on traditional media and 409 minutes on digital media. Fast forward to today, and traditional media consumption has dropped to 277 minutes per day, while digital usage has soared to 478 minutes per day, surpassing the previous peak of 470 minutes in 2020.

This shift underscores the growing dominance of digital channels in how people consume content, interact with brands, and make purchasing decisions. For businesses, this evolution presents a golden opportunity to connect with their audiences where they spend the majority of their time online.


Leveraging Digital Methods for Clinical Trial Advertising

The benefits of digital marketing extend far beyond retail or service industries; they’re transforming healthcare, particularly in patient recruitment for clinical trials. Finding eligible participants for clinical trials is a notoriously time-consuming and costly process. However, digital advertising provides a powerful solution by allowing companies to:

  1. Target Precisely: Digital platforms enable precise targeting, ensuring that advertisements reach individuals who meet the eligibility criteria for clinical trials.
  2. Optimize Costs: With access to detailed data on audience behavior and marketing performance, digital campaigns can be fine-tuned to avoid spending on audiences outside the target group. This cost efficiency is a significant advantage compared to traditional methods, which often involve broader, less specific outreach.
  3. Improve Results: Digital marketing platforms offer real-time performance insights, enabling continual adjustments to maximize results and minimize waste.


A Cost-Effective Approach to a Complex Challenge

Patient recruitment is already a costly endeavour, and traditional advertising methods often add to these expenses without delivering optimal results. Digital marketing, by contrast, provides a cost-effective alternative that reduces inefficiencies, improves targeting accuracy, and ultimately accelerates the recruitment process.

As the reliance on digital platforms grows, industries like healthcare can harness the power of digital advertising to overcome longstanding challenges and drive success in innovative ways.

Social Media Ads for Patient Recruitment

Social media platforms, particularly Facebook and Instagram, have emerged as powerful tools for connecting with potential patients. With over 3 billion monthly active users on Facebook and more than 2 billion on Instagram, the reach and impact of these platforms are unparalleled.


Highly Targeted Ad Campaigns with Meta's Tools

Meta, the parent company of Facebook and Instagram, offers sophisticated tools for running highly targeted ad campaigns. These tools allow companies to filter audiences based on demographics, interests, locations, and more. For example, clinical trials can use these filters to target specific age groups and geographical areas, ensuring that the clinical trial recruitment ads are shown to individuals most likely to meet eligibility criteria.

This precision targeting not only improves the effectiveness of campaigns but also minimizes wasted efforts by focusing on the right audience from the start.


Capitalizing on Social Media Usage Trends

In the U.S., the average screen time is 7 hours and 3 minutes daily, with 2 hours and 14 minutes spent on social media. These numbers make platforms like Facebook and Instagram ideal for reaching a broad audience of potential candidates for clinical trials.

The choice between Facebook and Instagram can also be tailored to the trial’s needs:

  • Instagram is particularly effective for reaching younger demographics, making it ideal for trials targeting younger participants.
  • Facebook appeals to an older user base, making it suitable for trials with broader age eligibility requirements.

Understanding the age distribution on these platforms is key to crafting a successful social media strategy.


Real-Time Insights for Campaign Optimization

One of the biggest advantages of Meta’s platforms is access to real-time performance data. These insights allow patient recruitment companies to monitor and adjust campaigns dynamically, ensuring optimal performance and higher conversion rates. This level of control and adaptability sets paid social media advertising apart from traditional methods.


The Push-Strategy Advantage for Patient Recruitment

Paid social media advertising is an effective push-strategy for exposing clinical trials to a wide audience. By presenting potential patients with well-crafted and targeted ads, patient recruiters can spark interest, educate candidates, and ultimately convince them to enroll in the trial.

With its unparalleled reach, precision targeting, and powerful analytics, social media advertising is transforming patient recruitment for clinical trials, making it faster, more efficient, and cost-effective.

Learn more about how social media advertising can be used for clinical trial recruitment

Display Ads for Clinical Trial Advertising

Display ads are a powerful and versatile tool for patient recruitment on the internet. These ads appear in various formats across websites and mobile apps, providing widespread exposure. With platforms like the Google Display Network, which reaches over 90% of internet users worldwide, display ads are an excellent strategy for creating awareness about clinical trials.


The Reach and Impact of Display Ads

Similar to sponsored paid media posts, display ads offer a wide-reaching approach to capturing the attention of potential patients during the recruitment process. Their ability to appear across diverse platforms ensures that clinical trial advertising campaigns gain broad visibility, reaching potential participants wherever they are online.


The Advantages of Display Ads

One of the standout benefits of display ads is their versatility. These ads support a range of formats like images, videos, animations, and interactive elements, providing greater creative freedom to design attention-grabbing content. This flexibility allows organizations to craft ads that stand out, improving visibility and engagement with the target audience.

Additionally, display ads can be strategically placed on websites that attract a target audience relevant to the clinical trial. By focusing on platforms frequented by potential participants, these ads maximize their effectiveness and help ensure that recruitment efforts are directed toward the right people.

Reconnecting with Potential Participants Through Retargeting Ads

Retargeting ad campaigns are an essential tool in digital advertising for clinical trials, offering a strategic way to reconnect with users who have previously interacted with your ads. These users may have shown interest by visiting a landing page without completing the sign-up process for the trial. Retargeting ensures that these potential participants see your ads multiple times, increasing the likelihood that they will take action in the future.


Why Retargeting Ads Are So Effective

Unlike traditional ads that target cold leads, retargeting focuses on quality leads - those who have already demonstrated interest in the research study. This approach significantly boosts the chances of conversion. In fact, studies show that retargeting ads are 70% more likely to convert users compared to ads targeting new audiences. This higher likelihood of engagement makes retargeting a valuable addition to any clinical trial marketing campaign.


The Power of Repetition

The average person is exposed to thousands of ads daily, making it essential for companies to repeatedly expose their target audience to their message to ensure it resonates. While the exact number of exposures needed to convert a user can vary, the Rule of 7 suggests that a prospect needs to see an advertiser’s message at least seven times before they take action. Retargeting ads make this possible by keeping your clinical trial top-of-mind for potential participants, encouraging them to move from interest to enrollment.

Using Lookalike Audiences in Clinical Trial Advertising

Lookalike audiences are a game-changing tool in patient recruitment for clinical trials. Once a group of patients has passed the screening process and enrolled, this strategy leverages their data to identify and target individuals with similar characteristics, enhancing recruitment efficiency and success.


What Are Lookalike Audiences?

A lookalike audience is a group of people who share similar traits with existing participants. By analyzing data from current enrollees such as demographics, interests, and online activity, digital platforms like Meta can create Lookalike audiences from custom audiences based on people that has, for example, signed up to the study or been on the landing page for x amount of time.


How Lookalike Audiences Enhance Recruitment

Using this method allows companies to:

  1. Refine targeting: Focus on individuals who closely resemble those already qualified for the trial.
  2. Increase efficiency: Reduce time spent reaching unqualified leads by honing in on a highly relevant audience.
  3. Boost success rates: By targeting people with similar traits to those who have already enrolled, the likelihood of successful recruitment increases significantly.

Specifying the Details of the Clinical Trials

One of the most effective ways to minimize wasted advertising spend on ineligible audiences is by being specific about the details of the clinical trial, particularly the eligibility criteria. Clearly stating the requirements, such as location and patient qualifications, can help ensure that the clinical trial recruitment ads reach the right individuals.


The Benefits of Clarity in Eligibility Criteria

By clearly outlining eligibility criteria in the clinical trial advertising material, potential participants can quickly determine if they meet the desired profile. This transparency:

  • Reduces irrelevant sign-ups: It limits inquiries and registrations from individuals who don’t meet the study’s requirements.
  • Saves time and resources: Recruiters spend less effort screening unqualified candidates.


Specifying Location for Practical Impact

Including the location of the clinical trial prominently in the ad materials is particularly effective. This prevents sign-ups from individuals who live too far away to participate, further refining the target audience and reducing wasted effort.

Another crucial benefit of this approach is preventing false hope, especially for individuals with rare conditions. Clearly communicating requirements helps set realistic expectations, maintaining trust and credibility in a field where treatment potential is deeply personal.

Specificity in clinical trial advertising also helps reduce Cost per Clicks (CPC) by limiting interactions from ineligible individuals. Over time, this can result in significant cost savings, allowing budgets to be focused on reaching qualified candidates more effectively.

Paid Search Clinical Trial Advertising

Every day, over 8.5 billion searches are made on Google, making it a powerful platform for reaching individuals who are actively looking for specific information. For clinical trials, paid search advertising, or Search Engine Marketing (SEM), is an effective tool for connecting with individuals interested in trial opportunities.


Why Paid Search Ads Work for Patient Recruitment

Paid search advertising is a pull-strategy, meaning it targets individuals who are already searching for specific medical terms or clinical trials. By reaching out to these active searchers, patient recruitment recruiters can engage with people who are more likely to be interested in enrolling in a clinical trial. These users are considered high-quality leads, making them more likely to convert.


Optimizing Paid Search for Cost-Effective Recruitment

Since CPC (Cost Per Click) rates are often higher for paid search ads compared to other types of paid media, it’s crucial to optimize the clinical trial recruitment ads to ensure cost-effectiveness. Using keywords related to the specific condition and location of the trial, and narrowing down the ads by demographics, helps target the right audience while minimizing unnecessary costs.

Reducing Friction in the Pre-Screening Process for Clinical Trials

Finding and participating in clinical trials has never been easier for patients. A critical step in the recruitment process is filling out medical questionnaires during pre-screening. Making it simple and convenient to complete these questionnaires digitally, from the comfort of home, helps attract a larger pool of potential participants.


Streamlining the Process with In-Ad Pre-Screening

One key strategy to improve recruitment conversion rates is to embed the pre-screening questionnaire directly within the landing page of paid media ads. By presenting the questionnaire early, when a potential participant's interest has already been piqued, this approach reduces friction in the process. The result is higher recruitment-conversion rates, as participants are more likely to sign up immediately without additional steps or delays.


Overcoming Barriers with Digital Clinical Trial Advertising

A major challenge with traditional media is that potential participants must navigate to a digital platform on their own to complete the pre-screening process. This creates a significant barrier that reduces conversion rates. By eliminating these obstacles and making the transition to the digital pre-screening process seamless, digital marketing enables a more efficient and user-friendly experience for patients.


Simplifying Patient Tracking with Patiro Management System

At Patiro, we use our Patiro Management System to help sponsors, CROs, and sites easily track patients and activities throughout the recruitment process. This system provides a clear, user-friendly overview, ensuring a streamlined experience and allowing recruitment teams to efficiently monitor progress. Learn more about our services on our website.

Continuous Adaptation and Optimization in Clinical Trial Advertising

In any industry, consumer behavior rarely unfolds exactly as expected, and the patient recruitment process is no exception. The digital landscape is constantly evolving, making it essential for recruitment campaigns to continuously adapt and optimize their advertising strategies to stay effective and cost-efficient.


The Need for Ongoing Optimization

Even with access to data from previous campaigns targeting the same disease, consumer behavior and the algorithms on social media platforms are always shifting. As a result, it's crucial to continuously adapt the advertising materials to match these changes.

When recruiting for new diseases, it’s even more important to leverage digital tools to understand what resonates with a specific target group. Using the data gathered from ongoing campaigns, patient recruitment teams can refine their approach to ensure the most effective outreach.


The Role of Adaptation in Social Media Advertising

This is particularly relevant in social media advertising, where the competition for attention is fierce. Social media feeds are saturated with content designed to capture users' interest, making it essential to create engaging and eye-catching material. Today’s consumers, particularly younger audiences, have shorter attention spans, driven in part by the rise of short-form content on platforms like TikTok, Instagram, Facebook, and YouTube.

As consumers become increasingly selective about the content they engage with, it’s crucial for advertisements to stand out quickly and maintain the viewer's attention. This makes monitoring performance and adapting to the data a key strategy for taking full advantage of the opportunities offered by digital marketing for clinical trials.


Planning for Flexibility in Clinical Trial Advertising

To maximize success, it's beneficial to have a clear understanding of the target audience and anticipate potential challenges ahead of time in the approved IRB documentation for the study. This foresight allows for flexibility in making changes to the clinical trial advertising strategy as the campaign evolves.

Adapting ethically and within regulatory boundaries is essential for a successful patient recruitment campaign, ensuring both effectiveness and compliance.

Regulations and Their Impact on Digital Marketing for Clinical Trials

While digital advertising offers great reach and efficiency for patient recruitment, it operates within a highly regulated space. Compliance with these regulations is essential to ensure ethical practices, protect patient rights, and maintain the integrity of clinical trial marketing.


The Role of HIPAA and Other Regulations

One of the key regulations affecting digital marketing in the healthcare sector is HIPAA (Health Insurance Portability and Accountability Act) in the US. HIPAA safeguards sensitive patient data and imposes strict conditions on its use, particularly concerning how cookies and patient information are managed online. Ensuring compliance with HIPAA is crucial for protecting patient privacy throughout the recruitment process.

Regulations governing digital advertising can vary significantly, not only across countries but also within regions of the same country. For instance, California's CCPA (California Consumer Privacy Act) gives residents greater control over their personal data. This law mandates transparency in data collection practices and grants consumers the right to opt-out of data sales, which affects how companies use cookies for tracking and targeting users.


The Impact of New Regulations on Digital Advertising

In late 2023, Google introduced Consent Mode V2, which changed how user consent is managed in digital advertising. This update introduced stricter requirements for securing and documenting consent from users, ensuring compliance with privacy laws like the GDPR in the EU. This development underscores the need for companies to be proactive in securing consent and managing data within the evolving regulatory landscape.


Staying Compliant and Ethical in Clinical Trial Advertising

Given the rapidly changing regulatory environment, it is crucial for patient recruitment companies to stay informed about the latest legal changes to ensure they follow ethical advertising practices. Staying up to date with both clinical trial regulations and general privacy laws will help safeguard patient data, maintain compliance, and enhance the effectiveness of digital advertising strategies.

Learn more about how patient recruitment companies handle regulation in clinical trial advertising

The Power of Digital Advertising in Patient Recruitment

Digital advertising has revolutionized the ability to target individuals who are more likely to meet clinical trial eligibility criteria. This makes it an exceptionally effective tool in today’s digital landscape, where people are spending more time online than ever before.

By leveraging digital tools for clinical trial advertising, patient recruitment companies can cost-effectively reach a diverse range of individuals, ensuring they meet enrollment and scheduling targets for clinical trials. However, achieving a broader and faster reach while adhering to regulatory requirements can be a complex challenge.


Patiro’s Expertise in Digital Clinical Trial Advertising

This is where Patiro excels. Specializing in digital marketing for clinical trials, Patiro collaborates with some of the world’s largest pharmaceutical companies, assisting them in recruiting eligible patients globally.

With more than 10 years of experience in the industry, Patiro has successfully enrolled patients in over 44 countries, covering more than 2,000 diseases, including rare diseases, oncology, CNS, psychiatry, pediatrics, and many more.

Schedule a demo today to learn more about how we can help you.

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